Intravenous injection of extracellular vesicles to treat chronic myocardial ischemia
Background Mesenchymal stem cell-derived extracellular vesicles (EVs) appear to be a very exciting treatment option for heart disease.Here, we used a swine model of chronic myocardial ischemia to evaluate the efficacy of a less-invasive method of injection of EVs via a peripheral intravenous route.Methods Sixteen Yorkshire swine underwent placement